However, reactive oxygen species (ROS) are often overproduced under pathological conditions, resulting in oxidative stress. Oxidation is essential to many organisms for the production of energy to fuel biological processes. In addition, ten proanthocyanidins were isolated from MGEB, and six of them were firstly reported from this plant.
Furthermore, MGEB could significantly protect against CCl 4 induced acute liver injury through inhibition of oxidative stress in mice. The fraction MGEB, which was obtained by 60% ethanol extraction and followed by a further separation with D101 resin column chromatograph, possessed the highest proanthocyanidin content and the highest free radical scavenging and antioxidant activities. We observed total of six extracts and fractions, which were easily obtained by water-ethanol extraction and followed by a further separation with D101 resin column chromatography, had significant DPPH radical, superoxide anion radical, and hydroxyl radical scavenging capacity, total antioxidative capacity (T-AOC), lipid peroxidation inhibitory activity, and metal ions chelating capacity.
This study is the first to report the free radical scavenging capacity, antioxidant activity, and proanthocyanidin composition of the bark of M. glyptostroboides are used as antimicrobic, analgesic, and anti-inflammatory drug for dermatic diseases. In the Chinese folk medicine, the leaves and bark of M.
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